干姜的化学成分研究

崔婉华,王彦志,李泽之

中国药学杂志 ›› 2018, Vol. 53 ›› Issue (14) : 1160-1164.

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中国药学杂志 ›› 2018, Vol. 53 ›› Issue (14) : 1160-1164. DOI: 10.11669/cpj.2018.14.004
论著

干姜的化学成分研究

  • 崔婉华1,2,王彦志1,2*,李泽之1,2
作者信息 +

Chemical Constituents from Rhizoma Zingiberis

  • CUI Wan-hua1,2,WANG Yan-zhi1,2*, LI Ze-zhi1,2
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文章历史 +

摘要

目的 研究干姜的化学成分。方法 利用Diaion HP-20,Toyopearl HW-40,ODS,硅胶柱及半制备液相等多种色谱技术进行分离纯化,根据化合物的理化性质和光谱数据鉴定结构。结果 从干姜中分离并鉴定15 个化合物,结构分别为renealtin A(1),kravanhol A(2),1,7-bis(3, 4-di-hydroxyphenyl)-3-heptanone(3),二氢海因酮C(4),1,7-bis(3, 4-dihydroxyphenyl)heptan-3-ylacetate(5),(5R)-1, 7-双(3,4-二羟基苯基)-3-羟基苯基庚烷(6),山橘脂酸(7),4-(1-甲氧基乙基)-苯酚(8),3-吲哚甲醛(9),3,4二甲氧基苯乙酸(10),(2E,6E)-2, 6-dimethylocta-2, 6-dienedioic acid(11),cyclo-(D-Leu-L-Trp)(12),cyclo-(S-Pro-S-Phe)(13),8-羟基香叶醇(14)和(Z)-2, 6-二甲基辛-6-烯-1, 8-二醇(15)。结论 其中化合物1~6为二苯庚烷类化合物,化合物1~15均为首次从该植物中分离得到。

Abstract

OBJECTIVE To study the chemical constituents of Rhizoma Zingiberis. METHODS Diaion HP-20, Toyopearl HW-40, ODS, silica gel column and semi-preparation liquid were used to separate and purify the structure, and the structure was identified according to the physical and chemical properties and spectral data of the compound. RESULTS Fifteen compounds were isolated and identified from Rhizoma Zingiberis, which were renealtin A(1),kravanhol A(2),1, 7-bis(3,4-di-hydroxyphenyl)-3-heptanone(3),dihydrocannabinone C(4), 1, 7-bis(3, 2), 1, 7-bis(3,4-di-hydroxyphenyl) 4-dihydroxyphenyl) heptane-3-ylacetate(5),(5R)-1,7-bis(3, 4-dihydroxy)-3-hydroxyphenylheptane(6), citrus acid(7), citrate 4-(1-methoxyethyl)-phenol(8), 3-indolecarboxy(9), 3, 4-dimethoxyphenylacetic acid(10),(2E,6E)-2,6-dimethylocta-2, 6-dienedioicacid(11), cyclo-(D-Leu-L-Trp)(12), cyclo-(S-Pro-S-Phe)(13), 8-hydroxygeraniol(14) and (Z)-2, 6-dimethyloct-6-ene-1, 8-dihydroxy(15). CONCLUSION Compounds 1-15 were isolated from the plant for the first time.

关键词

干姜 / 二氢海因酮 / 二苯庚烷

Key words

Rhizoma Zingiberis / dihydrocannabinone C / diphenylheptane

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导出引用
崔婉华,王彦志,李泽之. 干姜的化学成分研究[J]. 中国药学杂志, 2018, 53(14): 1160-1164 https://doi.org/10.11669/cpj.2018.14.004
CUI Wan-hua,WANG Yan-zhi, LI Ze-zhi. Chemical Constituents from Rhizoma Zingiberis[J]. Chinese Pharmaceutical Journal, 2018, 53(14): 1160-1164 https://doi.org/10.11669/cpj.2018.14.004
中图分类号: R284   

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基金

河南中医药大学科技创新团队项目资助(2015XCXTD02)
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