目的 研究干姜的化学成分。方法 利用Diaion HP-20,Toyopearl HW-40,ODS,硅胶柱及半制备液相等多种色谱技术进行分离纯化,根据化合物的理化性质和光谱数据鉴定结构。结果 从干姜中分离并鉴定15 个化合物,结构分别为renealtin A(1),kravanhol A(2),1,7-bis(3, 4-di-hydroxyphenyl)-3-heptanone(3),二氢海因酮C(4),1,7-bis(3, 4-dihydroxyphenyl)heptan-3-ylacetate(5),(5R)-1, 7-双(3,4-二羟基苯基)-3-羟基苯基庚烷(6),山橘脂酸(7),4-(1-甲氧基乙基)-苯酚(8),3-吲哚甲醛(9),3,4二甲氧基苯乙酸(10),(2E,6E)-2, 6-dimethylocta-2, 6-dienedioic acid(11),cyclo-(D-Leu-L-Trp)(12),cyclo-(S-Pro-S-Phe)(13),8-羟基香叶醇(14)和(Z)-2, 6-二甲基辛-6-烯-1, 8-二醇(15)。结论 其中化合物1~6为二苯庚烷类化合物,化合物1~15均为首次从该植物中分离得到。
Abstract
OBJECTIVE To study the chemical constituents of Rhizoma Zingiberis. METHODS Diaion HP-20, Toyopearl HW-40, ODS, silica gel column and semi-preparation liquid were used to separate and purify the structure, and the structure was identified according to the physical and chemical properties and spectral data of the compound. RESULTS Fifteen compounds were isolated and identified from Rhizoma Zingiberis, which were renealtin A(1),kravanhol A(2),1, 7-bis(3,4-di-hydroxyphenyl)-3-heptanone(3),dihydrocannabinone C(4), 1, 7-bis(3, 2), 1, 7-bis(3,4-di-hydroxyphenyl) 4-dihydroxyphenyl) heptane-3-ylacetate(5),(5R)-1,7-bis(3, 4-dihydroxy)-3-hydroxyphenylheptane(6), citrus acid(7), citrate 4-(1-methoxyethyl)-phenol(8), 3-indolecarboxy(9), 3, 4-dimethoxyphenylacetic acid(10),(2E,6E)-2,6-dimethylocta-2, 6-dienedioicacid(11), cyclo-(D-Leu-L-Trp)(12), cyclo-(S-Pro-S-Phe)(13), 8-hydroxygeraniol(14) and (Z)-2, 6-dimethyloct-6-ene-1, 8-dihydroxy(15). CONCLUSION Compounds 1-15 were isolated from the plant for the first time.
关键词
干姜 /
二氢海因酮 /
二苯庚烷
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Key words
Rhizoma Zingiberis /
dihydrocannabinone C /
diphenylheptane
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中图分类号:
R284
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参考文献
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脚注
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基金
河南中医药大学科技创新团队项目资助(2015XCXTD02)
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